In order to minimize swelling and reduce downtime, it is advised to pre-treat patients with an anti-histamine, such as Benadryl. This will block the body's response to the HA, thereby reducing swelling and ensuring minimal downtime. Patients may continue with the antihistamine until the swelling has completely subsided. Ice packs may also be used in 20 minute intervals (20 minutes on, 20 minutes off) for the first 24 hours. The individual should be seen at 1 to 2 weeks after the injection to assess for any irregularities, such as too much product clumped into one area. If this is found it may be massaged out (only to be performed by the physician or under the physician's instructions). If massaging does not alleviate the irregularity, injection of hyaluronidase may be performed. A typical dose is 10 to 15 units injected with local anesthesia and adrenaline to limit the area affected by the enzyme.